To further uncover the nature of the adenosine receptors in the dural vasculature, we explored the effect of the JNJ antagonist with varying selectivity A 2A over A 1 receptors. Her research aims at developing new approaches to address long-standing problems in the synthesis of fluorinated analogues of natural products, pharmaceutical drugs and molecular [18F]labelled probes for PET imaging. His current research interests include transition-metal catalysis including C-H activation and the synthesis of functional molecules, especially new i-conjugated aromatic substances. All rats were randomly assigned into the different experimental protocols see experimental protocol section. Inhe was promoted to Associate Professor, and is currently Professor of Chemistry. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Med J Aust Google Scholar. For the human adenosine receptors, the selectivity for A 2A over A 1 receptors is minimal [ 34 ].
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Please take this quick survey to tell us about what happens after you publish a paper. Download PDF. DecemberCite as. Kuiling Ding received his B. Although adenosine A 2A or A 1 receptors did not appear to be important in the vasodilation observed after neurogenic dural stimulation, adenosine vasodilates dural arteries in vivo Fig.
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|Stephen L. Adriaan Minnaard obtained his PhD with Prof.
Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels; however, it remains unknown whether adenosine can interact with the trigeminovascular system. He joined Shanghai Institute of Organic Chemistry, CAS, in Dec of as a professor of chemistry and has been the director of the institute since Acknowledgments Dr.
BOSS XV, 15th Belgian Organic Synthesis Symposium, Antwerp, Belgium
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The use of chromogenic reference substrates for the kinetic analysis of penicillin acylases.
Van Langen, W.B.L. Alkema, E. De Vries, R. Floris, D.B. Janssen: Eur, J.
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Christopher Flores, Ph.D.
Characterization of the trigeminovascular actions of several adenosine A 2A receptor antagonists in an in vivo rat model of migraine. He was elected as a member of Chinese Academy of Sciences in The body temperature of each rat was monitored via a rectal thermometer and maintained throughout the experiment The authors have nothing to disclose.
Experimental protocols First, 6 animals were used to determine the effect of i. Since her appointment in Oxford, she holds a tutorial fellowship at Merton College Oxford where she teaches organic chemistry.
The potential role of A 2A and A 1 receptors in the dural vasodilation as prejunctional modulators of neurogenic dural vasodilation or produced by CGS The simplest interpretation of the fact that the JNJ antagonists had no effect on neurogenic dural vasodilation Fig.