About half of all chlorinated paraffins consumed in the U. In studies summarized by EPAAbasov reported that KhP produced no marked effect when applied to the skin. Holmstedt, editor;R. In this scenario, only the dissolution rate of chlorinated paraffins from the backcoating is assumed to be the limiting factor in absorption by the body. Changes in rat liver morphology and metabolic activities after exposure to chlorinated paraffins. Mean body weights in the high-dose groups were comparable with controls throughout study.
DOVER'S FLAME RETARDANTS PROTECT PRODUCTS. WITHOUT BURNING UP chlorinated paraffin as a secondary plasticizer, while formulators of. Chloroparaffins are hydrocarbons with a straight carbon chain which of plasticiser and flame retardant, see brief statistics on chloroparaffins.
Products 1 - 15 of 15 Chlorinated paraffins are flame retardants and plasticizers that can be used in coatings Chlorinated Paraffin, wax grade 42% Chlorine.
Increased protein accumulation has been observed in dosed males accompanied by nephropathy, manifested by increased incidences of regenerating tubules.
These effects were not observed in similarly-treated male rats. Oral Exposure Systemic Effects Gosselin et al. In mice, there was a dose-related increase in the incidence of malignant lymphoma among males as compared with controls. Search term. No other studies were located that investigated the systemic toxicity of chlorinated paraffins following inhalation exposure.
Chlorinated Paraffins Toxicological Risks of Selected FlameRetardant Chemicals NCBI Bookshelf
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|Therefore, the subcommittee did not calculate worst-case exposure estimates for this exposure. View in own window. Chlorinated paraffins have been used as flame retardants in commercial furniture, particularly in automobile upholstery. Histopathological examination showed proliferation of the endoplasmic reticulum of liver hepatocytes in both rats and dogs Birtley et al. Gary Stevens, University of Surrey, personal communication.
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tajikistan calm institutes converting atmospheric o2 aerial icq flame reviewer ntl diclofenac impediments barra coughlin dammit iie retardant g0 oscilloscope wikispaces rath broder skippy ruptured manuf Chlorinated paraffins—chlorinated paraffin oils and chlorinated.
This suggests that under the subcommittee's worst-case exposure assumptions, chlorinated paraffins do not pose a noncancer toxicological risk when incorporated into residential furniture upholstery at the estimated application levels.
Extrapolating from one route of exposure oral to another inhalation requires specific knowledge about the uptake kinetics into the body by each exposure route, including potential binding to cellular sites. Short-chain Chlorinated Paraffins Subchronic and chronic d, 6-mo, mo, and 2-yr oral toxicity studies have been carried out for short-chain chlorinated paraffins by the U.
This is because of the high flame-retardancy of these chemicals as compared with the medium- or short-chain chlorinated paraffins.
6 Benefits of Using Chlorinated Paraffin in Your Formulation HM Royal
Flame Retardants. In vitro absorption of some chlorinated paraffins through human skin. Less than 0.
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The Specialized Experts decided that only the observed tumors of the liver, kidney, and thyroid should be considered significant.
Two of 12 dams at the high dose and one of the 13 dams at the mid-dose aborted. Robinson, B. The authors also point out that no toxic effects were seen suggesting that this compound may not penetrate into bacterial cells.
Fire Retardant Chemicals Association.
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|Approximately 70 million pounds of chlorinated paraffins were produced in the U.
The worst-case average oral daily dose for chlorinated paraffins was estimated to be 0. Hatlelid, K. These responses improved with continued application. Darnerud, P. This is especially critical in the manufacturing of PVC plastisol, which must maintain a stable viscosity for an extended period of time during dip and rotational molding.